This study investigated the influence of self-efficacy on the academic performance of the Grade 12 Senior High School students at the St. Paul College of Bocaue. The findings of the study concluded that the level of the self-efficacy of the respondents was high. Likewise, the findings suggested that the students are resilient and determined in the face of setbacks, feel assured that they will be able to learn the classroom discussion and excel on their assessment, and they tend to be more intrinsically motivated to learn new knowledge. Furthermore, the computed linear regression analysis results revealed that self-efficacy does not significantly affect the Senior High School students’ academic performance. This suggests that even if the students have a high level of self-efficacy it doesn’t influence their academic performance in class. However, it doesn’t mean that the school should not give importance to develop the students’ self-efficacy. Hence, it is suggested that the school should continue its academic programs that will continuously develop the student’s well-being in the process of acquiring relevant experiences and skills in the school.